Sequential stopping for high-throughput experiments

In high-throughput experiments, the sample size is typically chosen informally. Most formal sample-size calculations depend critically on prior knowledge. We propose a sequential strategy that, by updating knowledge when new data are available, depends less critically on prior assumptions. Experiments are stopped or continued based on the potential benefits in obtaining additional data. The underlying decision-theoretic framework guarantees the design to proceed in a coherent fashion. We propose intuitively appealing, easy-to-implement utility functions. As in most sequential design problems, an exact solution is prohibitive. We propose a simulation-based approximation that uses decision boundaries. We apply the method to RNA-seq, microarray, and reverse-phase protein array studies and show its potential advantages. The approach has been added to the Bioconductor package gaga

Network anomaly detection: a survey and comparative analysis of stochastic and deterministic methods

7 pages. 1 more figure than final CDC 2013 versionWe present five methods to the problem of network anomaly detection. These methods cover most of the common techniques in the anomaly detection field, including Statistical Hypothesis Tests (SHT), Support Vector Machines (SVM) and clustering analysis. We evaluate all methods in a simulated network that consists of nominal data, three flow-level anomalies and one packet-level attack. Through analyzing the results, we point out the advantages and disadvantages of each method and conclude that combining the results of the individual methods can yield improved anomaly detection results

Double Think: The Cinema and Magic Lantern Culture

"Celebrating 1895" includes 27 of the finest papers presented at The Centenary of Cinema conference in June 1995. The first part discusses the reception of film as a new technology in the early part of the 20th century. The second focuses on exhibition and audiences. The relation of early film to popular culture forms the third part of the book, and through examining the way in which film as a new medium threw earlier definitions of the public and private sphere into disarray. The final part examines issues in the formal development of the medium and the response to initiatives arising from the 'new film history'

The Public Exhibition of Moving Pictures Before 1986

This article is an attempt to refresh our ideas of how moving pictures were invented and first seen. It is also an attempt to find one new way — of many possible ways — of discussing the earliest moving pictures, and in so doing to think again about which inventors or pioneers were significant in developing moving image culture

Nuernberg and the Bull's-Eye Magic Lantern

This is a revised and expanded version of an article first published in New Magic Lantern Journal, Vol. 9 No. 5 (Winter 2003), pp. 71-75, as “Some Thoughts on the Bull’s-Eye Magic Lantern"

Serpentine Dance: Inter-National Connections in Early Cinema

Text for the Honorary Research Fellow Lecture given at Goldsmith’s College, University of London, 27 October 1998, and later published under the above title as Occasional Papers in Modern Languages, Culture and Society, Issue No. 1, May 1999, by the Department of European Languages, Goldsmiths College, University of London

Combined theoretical and experimental study of the Moir\'e dislocation network at the SrTiO3_3-(La,Sr)(Al,Ta)O3_3 interface

Recently a highly ordered Moir\'e dislocation lattice was identified at the interface between a \ce{SrTiO3} (STO) thin film and the (LaAlO$_3$)$_{0.3}$(Sr$_2$TaAlO$_6$)$_{0.7}$ (LSAT) substrate. A fundamental understanding of the local ionic and electronic structure around the dislocation cores is crucial to further engineer the properties of these complex multifunctional heterostructures. Here we combine experimental characterization via analytical scanning transmission electron microscopy with results of molecular dynamics and density functional theory calculations to gain insights into the structure and defect chemistry of these dislocation arrays. Our results show that these dislocations lead to undercoordinated Ta/Al cations at the dislocation core, where oxygen vacancies can easily be formed, further facilitated by the presence of cation vacancies. The reduced Ti$^{3+}$ observed experimentally at the dislocations by electron energy-loss spectroscopy are a consequence of both the structure of the dislocation itself, as well as of the electron-doping due to oxygen vacancy formation. Finally, the experimentally observed Ti diffusion into LSAT around the dislocation core occurs only together with cation-vacancy formation in LSAT or Ta diffusion into STO